| Product name: |
ATG13 Rabbit pAb |
| Reactivity: |
Human, Mouse, Rat |
| Alternative Names: |
KIAA0652,?Apg13,Autophagy-related protein 13 antibody |
| Source: |
Rabbit |
| Dilutions: |
IHC 1:100-200 |
| Immunogen: |
Recombinant Protein |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1mg/mL |
| Observed Band: |
57kDa |
| GeneID: |
9776 |
| Human Swiss-Prot No: |
O75143 |
| Cellular localization: |
Cytoplasm |
| Background: |
Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions. |
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