| Product name: |
Collagen II (8F6) Mouse mAb |
| Reactivity: |
Human, Mouse, Rat |
| Alternative Names: |
Alpha 1 type II collagen , AOM, Col2a1 antibody |
| Source: |
Mouse |
| Dilutions: |
IHC 1:100-200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
142kDa |
| GeneID: |
1280 |
| Human Swiss-Prot No: |
P02458 |
| Cellular localization: |
Secreted,extracellular space,extracellular matrix |
| Background: |
Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice and higher primates which can resemble rheumatoid arthritis and relapsing polychrondritis. |
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