| Product name: |
Cleaved-Thrombin APII (R327) rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
F2; Prothrombin; Coagulation factor II |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human THRB. AA range:278-327 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
19kD |
| GeneID: |
2147 |
| Human Swiss-Prot No: |
P00734 |
| Cellular localization: |
Secreted, extracellular space. |
| Background: |
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015], |
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